Best Enzyme Dog Chews: Top Picks

Large dogs often struggle with plaque and tartar due to their powerful jaws and chewing habits. Enzyme chews like these help address dental buildup in a way that's easy to add to your routine.

This option from Virbac is designed specifically for large breeds, combining a dual-enzyme system with a textured, single-layer beef rawhide. It's ideal for owners seeking a vet-recommended chew that supports daily oral hygiene for bigger dogs.

• Dual-Enzyme System: Promotes effective plaque and tartar reduction for better dental health
• Single-Layer Beef Rawhide: Easier to digest than multi-layer alternatives
• Chicken Flavor: Appeals to most dogs, encouraging regular use

Compared to standard chews, this product prioritizes enzymatic action and digestibility for large dogs. The main tradeoff is that rawhide may not be suitable for dogs with sensitivities or those who gulp treats.

If you prefer to buy treats in smaller quantities or want to keep chews fresher, this 8.4oz bag is a practical solution. Dental health is important for all dogs, but smaller batch sizes help manage freshness and portion control.

This Virbac option offers the same dual-enzyme system and beef rawhide as their larger bags but in a more manageable size. It's a good fit for owners who want to try the product before committing to a larger supply or have a single dog.

• Small Batch Size: Helps maintain freshness and avoid waste
• Dual-Enzyme Action: Supports daily dental care
• Beef Rawhide Base: Provides effective mechanical cleaning

Compared to larger bags, this product focuses on convenience and freshness. The tradeoff is a higher cost per chew compared to bulk options.

Medium-sized dogs need dental chews that balance size, effectiveness, and digestibility. This product addresses the common challenge of finding a chew that's not too large or too small for medium breeds.

Virbac's medium dog chews are a reliable choice for daily dental care, offering the dual-enzyme system and a palatable chicken flavor. They're best for owners seeking a proven, all-purpose chew for dogs in the 26-50 lb range.

• Sized for Medium Dogs: Ensures appropriate chewing action and safety
• Dual-Enzyme Technology: Helps reduce plaque and tartar buildup
• Single-Layer Rawhide: Supports easier digestion

Compared to alternatives, this chew stands out for its balanced approach to size, enzyme support, and digestibility. The main tradeoff is that it may not suit dogs outside the medium size range.

Finding a dental chew that appeals to picky eaters can be difficult, especially for large dogs. Poultry flavor adds variety and can entice dogs who are less interested in beef-based treats.

Vet One's DuoClenz chews are formulated for large dogs and feature a palatable poultry flavor with dual-enzymatic coating. This makes them a strong choice for owners whose dogs prefer poultry over beef.

• Poultry Flavor: Appeals to dogs who prefer non-beef options
• Dual-Enzymatic Coating: Supports dental cleaning and fresher breath
• Large Size: Suitable for bigger breeds

Compared to beef-flavored chews, this product prioritizes flavor variety. The tradeoff is that poultry may not appeal to all dogs, and some may have sensitivities.

Small dogs often need chews that are easy to handle and digest, while still providing effective dental care. This product addresses the need for a poultry-flavored, enzyme-coated chew tailored for smaller breeds.

Vet One DuoClenz chews use a patented enzyme coating and abrasive texture to help keep teeth clean and breath fresh. They're ideal for owners of small dogs who want a poultry-flavored alternative to beef rawhide.

• Patented Enzyme Coating: Boosts enzymatic cleaning action
• Abrasive Rawhide Texture: Helps remove plaque and tartar
• Poultry Flavor: Increases palatability for selective eaters

Compared to standard small dog chews, this option emphasizes flavor and enzyme delivery. The tradeoff is that rawhide may not be suitable for all small dogs, especially those with sensitive digestion.

Medium dogs benefit from chews that combine effective cleaning with appealing flavor. This product targets owners looking for a unique enzyme application process and reliable dental support.

Vet One DuoClenz chews are made from North American beef hide and coated with a blend of two enzymes using a patented process. They're best for those who want a chew that maximizes enzymatic activity and supports daily oral hygiene for medium breeds.

• Patented Dual-Enzyme Coating: Enhances cleaning power
• North American Beef Hide: Quality base material
• Poultry Flavor: Increases acceptance among dogs

Compared to other chews, this product stands out for its enzyme coating process. The tradeoff is that it may not offer as many flavor options as some alternatives.

Dogs that chew quickly can miss out on the dental benefits of longer-lasting treats. This product is designed to provide extended chewing time, helping to maximize cleaning and freshening effects.

Real Hide's enzyme-enriched chews are made from premium, collagen-rich beefhide with a chicken flavor, ideal for medium and large dogs needing a durable chew. They're a good fit for owners who want to keep their dogs engaged while supporting oral health.

• Long-Lasting Chew: Promotes extended dental cleaning
• Collagen-Rich Beefhide: Supports gum and tooth health
• Chicken Flavor: Appeals to most dogs

Compared to softer or smaller chews, this product prioritizes durability and chew time. The tradeoff is that it may be too tough for some dogs or those with dental sensitivities.

Small dogs are especially prone to dental issues due to their mouth size and tooth spacing. Enzyme chews sized for small breeds help address these challenges by providing manageable, effective dental care.

This Virbac option is poultry-flavored and sized for dogs under 11 lbs, making it a practical choice for owners of toy and small breeds who want to support daily oral hygiene.

• Sized for Small Dogs: Ensures safe, effective chewing
• Dual-Enzyme System: Promotes plaque and tartar reduction
• Poultry Flavor: Increases palatability for small breeds

Compared to generic chews, this product prioritizes size and enzyme support for small dogs. The tradeoff is that it may not be suitable for larger pets or those with poultry sensitivities.

Some dogs have sensitivities to animal proteins or rawhide, making plant-based dental chews a valuable alternative. These chews address the need for effective tartar control without meat ingredients.

Virbac's VEGGIEDENT FR3SH chews are designed for medium dogs and feature a plant-based formula with a unique Z-shape for thorough cleaning. They're ideal for owners seeking a non-meat, gluten-free, and easily digestible option.

• Plant-Based Formula: Suitable for dogs with meat or rawhide sensitivities
• Unique Z-Shape: Helps reach all areas of the mouth
• Prebiotic Content: Supports healthy digestion

Compared to traditional rawhide chews, this product prioritizes ingredient transparency and digestibility. The tradeoff is that some dogs may prefer the taste of meat-based chews.

Some dogs have sensitivities to animal proteins or rawhide, making plant-based dental chews a valuable alternative. These chews address the need for effective tartar control without meat ingredients.

Virbac's VEGGIEDENT FR3SH chews are designed for medium dogs and feature a plant-based formula with a unique Z-shape for thorough cleaning. They're ideal for owners seeking a non-meat, gluten-free, and easily digestible option.

• Plant-Based Formula: Suitable for dogs with meat or rawhide sensitivities
• Unique Z-Shape: Helps reach all areas of the mouth
• Prebiotic Content: Supports healthy digestion

Compared to traditional rawhide chews, this product prioritizes ingredient transparency and digestibility. The tradeoff is that some dogs may prefer the taste of meat-based chews.