Best Digestive Enzyme For Dogs: Top Picks

James Vega | 30-01-2026

Digestive discomfort is a common issue for dogs, whether it’s due to diet changes, sensitive stomachs, or everyday stress. Symptoms like gas, loose stools, or irregular digestion can impact your dog’s well-being and make mealtimes a challenge for both pets and owners.

Digestive enzyme supplements offer a practical solution by supporting healthy digestion and nutrient absorption. This guide reviews the best digestive enzymes for dogs, comparing powders, chews, and blends with probiotics. You’ll find options for different needs, from sensitive tummies to dogs on processed or raw diets, so you can choose the right support for your companion.

Editor's Choice
NaturVet Digestive Enzymes Soft Chews
NaturVet Digestive Enzymes Soft Chews
Premium Pick
NaturVet Digestive Enzymes Powder Blend
NaturVet Digestive Enzymes Powder Blend
Budget Pick
Pro Plan Veterinary FortiFlora Canine Probiotic
Pro Plan Veterinary FortiFlora Canine Probiotic

Top 7 Best Digestive Enzyme For Dogs

After reviewing and comparing the most popular Best Digestive Enzyme For Dogs options, we identified the products that offer the best balance of quality, performance, and value.

1. NaturVet Digestive Enzymes Soft Chews

Best Chewable Treat-Style Enzyme
NaturVet Digestive Enzymes Soft Chews
9.8

Naturvet

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Digestive issues can make mealtime stressful for both dogs and their families, especially during diet changes or periods of digestive upset. A supplement that feels like a treat can make daily support much easier to provide.

NaturVet Digestive Enzymes Soft Chews combine enzyme support with probiotics and prebiotics in a tasty, resealable chew format. This product is ideal for pet owners who want a convenient, treat-like supplement that encourages compliance and freshness. It's especially suited for dogs who resist powders or capsules.

  • Soft chew format: Easy to administer and appealing to most dogs
  • Veterinarian formulated enzymes: Supports breakdown of starches, proteins, and fats
  • Resealable jar: Maintains product freshness and ease of storage

Compared to typical powders or capsules, these chews prioritize ease of use and palatability. However, owners seeking a precise or concentrated dose may prefer a powder format.

Strength
  • Tasty soft chew format
  • Includes probiotics and prebiotics
  • Easy to administer daily
  • Resealable packaging for freshness
  • Veterinarian formulated
Weakness
  • Less precise dosing than powders
  • Not suitable for dogs with treat aversion

2. NaturVet Digestive Enzymes Powder Blend

Best Powder for Diet Transitions
NaturVet Digestive Enzymes Powder Blend
9.5

Naturvet

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Switching your dog's food or recovering from illness can disrupt digestion, leading to discomfort and irregular stools. A concentrated enzyme powder can help smooth these transitions and support overall gut health.

NaturVet Digestive Enzymes Powder Blend is a vegetable-sourced formula designed for easy mixing with food. It's especially useful for dogs facing diet changes, post-deworming, or after illness. This powder is best for owners who want a versatile, mix-in supplement without added flavors or fillers.

  • Concentrated powder: Allows flexible, accurate dosing
  • Vegetable-derived enzymes: Suitable for sensitive dogs
  • Probiotics included: Supports normal digestion during transitions

Unlike chewable options, this powder offers more control over dosing and is ideal for dogs that may not accept treats. The tradeoff is that some dogs may resist powder on their food.

Strength
  • Accurate dosing control
  • Vegetable-based enzymes
  • Supports diet changes
  • Includes probiotics
  • No added flavors
Weakness
  • Some dogs may dislike powder texture
  • Requires mixing with food

3. NaturVet Digestive Enzymes Wheat Free

Best Wheat-Free Digestive Support
NaturVet Digestive Enzymes Wheat Free
9.1

Naturvet

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Dogs with sensitivities or allergies often need digestive support that avoids common allergens. Digestive enzyme supplements can help these dogs absorb nutrients more efficiently and handle dietary changes with less stress.

NaturVet Digestive Enzymes Wheat Free is formulated for dogs over six weeks old and provides essential enzymes for nutrient absorption. It's a strong choice for owners seeking a wheat-free option that still supports healthy digestion and diet transitions.

  • Wheat-free formula: Suitable for sensitive or allergic dogs
  • Supports nutrient absorption: Helps with digestion of essential nutrients
  • Designed for young and adult dogs: Versatile for different life stages

Compared to standard enzyme blends, this product prioritizes allergen avoidance. The main tradeoff is a narrower focus on wheat-sensitive dogs, which may not be necessary for all pets.

Strength
  • Wheat-free formulation
  • Supports diet transitions
  • Suitable for young dogs
  • Assists nutrient absorption
Weakness
  • Limited to wheat-sensitive needs
  • Powder format may be less convenient

4. Pan-tenex 10x Digestive Enzyme Powder

Best High-Potency Enzyme Formula
Pan-tenex 10x Digestive Enzyme Powder
8.9

Pan-tenex

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Some dogs require extra digestive support, especially those with pancreatic issues or severe digestive stress. A high-potency enzyme powder can help break down fats, proteins, and carbohydrates more effectively.

Pan-tenex 10x Digestive Enzyme Powder delivers maximum enzyme levels per dose, making it suitable for dogs needing robust digestive assistance. Its acetone-free, dust-free, and low-odor formulation is ideal for sensitive pets and owners who want a clean, potent supplement.

  • High enzyme concentration: Supports digestion of fats, proteins, and carbs
  • Low-odor, dust-free: Easier to handle and mix
  • Dosed per meal: Allows for tailored support and cost savings

Compared to standard enzyme powders, Pan-tenex stands out for potency and purity. The tradeoff is that its strength may be unnecessary for dogs with only mild digestive needs.

Strength
  • Very high enzyme potency
  • Low odor and dust-free
  • Customizable meal dosing
  • Supports nutrient absorption
  • Acetone-free formula
Weakness
  • May be too strong for mild cases
  • Powder requires careful dosing

5. NUSENTIA Enzyme Miracle Digestive Powder

Best Multi-Enzyme Plant-Based Blend
NUSENTIA Enzyme Miracle Digestive Powder
8.7

Nusentia

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Digestive problems in dogs and cats can stem from processed diets, food transitions, or sensitivities. A comprehensive enzyme supplement helps break down a wide range of nutrients, supporting smoother digestion and better overall health.

NUSENTIA Enzyme Miracle Digestive Powder offers 11 plant-based enzymes plus bromelain, making it a versatile choice for both dogs and cats. This unflavored powder is ideal for multi-pet households and those seeking a natural, additive-free supplement.

  • 11 plant-based enzymes: Breaks down proteins, fats, carbs, and fiber
  • Unflavored and pure: No animal ingredients, fillers, or flavorings
  • Third-party tested: Manufactured in a GMP-certified USA facility

Compared to animal-based or flavored supplements, this powder prioritizes purity and versatility. The tradeoff is that some pets may need additional flavor to accept it easily.

Strength
  • Multi-enzyme plant-based formula
  • Suitable for dogs and cats
  • No animal ingredients
  • Unflavored for easy mixing
  • Third-party tested
Weakness
  • Some pets may resist unflavored powder
  • No added palatability enhancers

6. YUMA'S Probiotics & Digestive Enzyme Chews

Best All-Ages Probiotic Chew
YUMA'S Probiotics & Digestive Enzyme Chews

Digestive discomfort can affect dogs at any age, from puppies to seniors. A chewable supplement that combines probiotics, prebiotics, and enzymes can help maintain gut health and comfort throughout your dog's life.

YUMA'S Probiotics & Digestive Enzyme Chews are formulated for all breeds and ages, providing relief from gas, loose stool, and upset stomach. This product is best for owners seeking a simple, veterinarian-developed chew that supports digestive balance in dogs of any life stage.

  • All-ages formula: Suitable for puppies, adults, and seniors
  • Advanced probiotic and enzyme blend: Addresses a range of digestive issues
  • Veterinarian developed: Manufactured in a USA FDA-registered facility

Compared to powders or single-focus supplements, these chews offer convenience and broad-spectrum support. The tradeoff is less dosing flexibility for dogs with very specific needs.

Strength
  • Suitable for all dog ages
  • Combines probiotics and enzymes
  • Chewable and easy to give
  • Veterinarian developed
  • Made in USA
Weakness
  • Less precise dosing than powders
  • Chew format may not suit all dogs

7. Zesty Paws Probiotics & Digestive Enzymes Chews

Best for Occasional Digestive Upset
Zesty Paws Probiotics & Digestive Enzymes Chews
8

Zesty Paws

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Dogs can experience occasional digestive upset from stress, dietary changes, or minor sensitivities. Supplements that combine enzymes with clinically studied probiotics help restore balance and support gut health during these times.

Zesty Paws Probiotics & Digestive Enzymes Chews use a blend of pumpkin, papaya, and six probiotic strains to support digestion and immune function. These chews are ideal for owners looking to address occasional diarrhea, gas, or bloating in a palatable, easy-to-serve format.

  • Six-strain probiotic blend: Supports gut flora and immune health
  • Pumpkin and papaya base: Natural sources of digestive enzymes
  • Clinically studied DE111 probiotic: Backed by research for digestive support

Compared to basic enzyme supplements, Zesty Paws focuses on occasional digestive issues and immune support. The tradeoff is that it may not be as targeted for chronic or severe digestive conditions.

Strength
  • Addresses occasional digestive upset
  • Includes multiple probiotic strains
  • Soft chew format
  • Supports immune system
  • Natural enzyme sources
Weakness
  • Not for chronic digestive issues
  • Chews may not suit all dogs

Buying Guide: How to Choose the Best Digestive Enzyme for Dogs

Digestive enzyme supplements for dogs come in a variety of forms and blends, each designed to address specific digestive challenges. Choosing the right product involves understanding your dog's unique needs, the differences between powders and chews, and the role of probiotics and prebiotics. Many buyers mistakenly assume all digestive aids are the same, but ingredient sources, dosing flexibility, and format can make a significant difference in effectiveness and ease of use.

Choosing Between Chews and Powders

The choice between chewable and powder supplements often comes down to your dog's preferences and your routine. Chews are easy to give and feel like a treat, making them ideal for picky eaters or busy households. Powders, on the other hand, allow for more precise dosing and can be mixed directly into food, which is helpful for dogs with specific dietary needs or those who dislike treats.

Understanding Enzyme and Probiotic Blends

Some products focus solely on digestive enzymes, while others combine enzymes with probiotics and prebiotics. Enzyme-only supplements are best for dogs with known enzyme deficiencies or pancreatic issues. Blended formulas offer broader support, helping with both digestion and gut flora balance, which is useful during diet changes or after illness.

Allergen-Free and Sensitive Stomach Options

If your dog has allergies or sensitivities, look for wheat-free, dairy-free, or additive-free formulas. Plant-based enzyme blends are often gentler and suitable for multi-pet households, including cats. Always check the ingredient list to avoid unwanted fillers or animal proteins if your pet is sensitive.

Matching Potency to Your Dog's Needs

High-potency enzyme powders are designed for dogs with significant digestive challenges, such as pancreatic insufficiency. For most dogs, a standard or gentle blend is sufficient and avoids unnecessary supplementation. Over-supplementing can sometimes cause digestive upset, so match the product strength to your dog's actual needs.

Final Buying Advice

Selecting the right digestive enzyme supplement is about matching your dog's needs with the right format, potency, and ingredient profile. Avoid assuming that more is always better, and consider your pet's preferences and sensitivities for the best results.

FAQ For Digestive Enzyme For Dogs

1. What do digestive enzymes do for dogs?

Digestive enzymes help dogs break down food into nutrients, supporting better digestion, nutrient absorption, and reducing issues like gas, bloating, or irregular stools.

2. How do I choose between powder and chewable enzyme supplements?

Choose chews for convenience and palatability, especially for picky eaters. Powders offer more precise dosing and are ideal for dogs with specific needs or those who dislike treats.

3. Can I give digestive enzymes to puppies or senior dogs?

Yes, many enzyme supplements are suitable for all life stages. Always check the product label for age recommendations and consult your veterinarian if unsure.

4. Are there side effects to giving my dog digestive enzymes?

Most dogs tolerate digestive enzymes well, but over-supplementation can cause mild digestive upset. Start with the recommended dose and monitor your dog's response.

5. Do I need a veterinarian's recommendation for these supplements?

While many digestive enzyme supplements are available over the counter, it's best to consult your veterinarian, especially if your dog has ongoing digestive issues or other health conditions.

6. Can digestive enzymes be given with probiotics?

Yes, many products combine enzymes and probiotics for broader digestive support. This combination can help with both nutrient breakdown and gut flora balance.

James Vega

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