Best Heartguard Plus Small Dogs 0-22lbs Chewables: Top Picks

James Vega | 24-04-2026

Heartworm disease is a serious risk for small dogs, and prevention is far easier than treatment. Many pet owners worry about choosing the right medication, especially with different brands and formulas available, and want something their dog will actually take.

This guide reviews the best chewable heartworm preventives for small dogs, focusing on ease of use, spectrum of protection, and real-world convenience. We break down the differences between top products so you can confidently choose the right option for your pet’s needs.

Editor's Choice
HEARTGARD Plus Chewables for Dogs up to 25 lbs, 6 Month
HEARTGARD Plus Chewables for Dogs up to 25 lbs, 6 Month
Premium Pick
HEARTGARD Plus Chewables for Dogs up to 25 lbs, 1 Month
HEARTGARD Plus Chewables for Dogs up to 25 lbs, 1 Month
Budget Pick
TRI-HEART PLUS Chewable Tablets for Dogs up to 25 lbs, 6 Month
TRI-HEART PLUS Chewable Tablets for Dogs up to 25 lbs, 6 Month

Top 7 Best Heartguard Plus Small Dogs 0-22lbs Chewables

After reviewing and comparing the most popular Best Heartguard Plus Small Dogs 0-22lbs Chewables options, we identified the products that offer the best balance of quality, performance, and value.

1. HEARTGARD Plus Chewables for Dogs up to 25 lbs, 6 Month

Best Long-Term Protection for Small Dogs
HEARTGARD Plus Chewables for Dogs up to 25 lbs, 6 Month
9.8

Heartgard

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Preventing heartworm and intestinal worms is crucial for small dogs, who are especially vulnerable to these parasites. A reliable monthly chewable can help avoid costly treatments and keep your pet healthy year-round.

HEARTGARD Plus 6-Month supply stands out for its vet-recommended formula and real-beef flavor, making it easy for most dogs to accept. It's ideal for owners who want a trusted, long-term solution from a widely used brand.

  • 6-month supply: Reduces the need for frequent reordering and helps maintain consistent protection
  • Real-beef chewable: Appeals to picky eaters and encourages compliance
  • Broad-spectrum coverage: Prevents heartworm and controls roundworms and hookworms

Compared to single-dose or shorter-term options, this pack prioritizes convenience and peace of mind for small dog owners. The main tradeoff is a higher upfront cost, but it saves time and effort over the long run.

Strength
  • 6-month supply for convenience
  • Real-beef flavor most dogs enjoy
  • Covers heartworm, roundworms, hookworms
  • Widely trusted brand
  • Vet-recommended
Weakness
  • Higher initial cost
  • Not suitable for dogs with beef allergies

2. HEARTGARD Plus Chewables for Dogs up to 25 lbs, 1 Month

Best for First-Time Users
HEARTGARD Plus Chewables for Dogs up to 25 lbs, 1 Month
9.5

Heartgard

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Choosing the right heartworm preventive can feel overwhelming, especially if you’re trying it for the first time or want to see how your dog reacts. A single-dose option lets you test for palatability and tolerance without committing to a full supply.

HEARTGARD Plus 1-Month pack offers the same trusted formula in a trial-friendly size. It’s well-suited for new users, dogs with sensitive stomachs, or those switching medications.

  • Single-month pack: Lets you try before buying in bulk
  • Real-beef chewable: Encourages acceptance by picky eaters
  • Trusted formula: Covers heartworm, roundworms, and hookworms

Unlike larger packs, this option prioritizes flexibility and minimizes waste if your dog doesn’t take to the chew. The tradeoff is the need to reorder monthly if you continue.

Strength
  • Good for trying before committing
  • Same protection as larger packs
  • Easy to administer
  • No long-term storage needed
Weakness
  • Requires frequent reordering
  • Less cost-effective over time

3. TRI-HEART PLUS Chewable Tablets for Dogs up to 25 lbs, 6 Month

Best Beef-Free Option for Allergies
TRI-HEART PLUS Chewable Tablets for Dogs up to 25 lbs, 6 Month
9.1

Tri-heart Plus

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Dogs with beef allergies can’t always tolerate standard heartworm chews, making it important to find a safe alternative that still offers complete protection. This product provides a solution for those sensitive pets.

TRI-HEART PLUS 6-Month supply delivers heartworm, roundworm, and hookworm prevention in a beef-flavored tablet that is safe for dogs with beef allergies. It’s a practical choice for owners who need to avoid certain ingredients without sacrificing efficacy.

  • Beef-free formula: Suitable for dogs with beef sensitivities
  • 6 chewable tablets: Covers six months of protection
  • Comprehensive parasite control: Prevents heartworm and treats intestinal worms

Compared to real-beef chews, this tablet prioritizes allergy safety and broad protection. The tradeoff is that some dogs may prefer a softer chew texture.

Strength
  • Safe for beef-allergic dogs
  • 6-month supply
  • Covers multiple parasites
  • Easy monthly dosing
Weakness
  • Tablet texture may not appeal to all dogs
  • Flavor may differ from real-beef chews

4. HEARTGARD Plus Chewables for Dogs 51-100 lbs, 6 Month

Best for Large Dog Households
HEARTGARD Plus Chewables for Dogs 51-100 lbs, 6 Month
8.9

Heartgard

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Large dogs face the same risks from heartworm and intestinal worms, and finding a product sized for them is essential for effective dosing. Owners with multiple dog sizes often need to buy different packs.

HEARTGARD Plus for 51-100 lbs dogs is designed for bigger breeds, offering the same trusted formula in a size-appropriate chew. It’s best for households with large dogs or mixed-size pets needing tailored protection.

  • Sized for large dogs: Ensures correct dosing for bigger breeds
  • 6-month supply: Reduces the need for frequent purchases
  • Comprehensive coverage: Prevents heartworm and treats roundworms and hookworms

Compared to small dog formulas, this pack prioritizes accurate dosing for large pets. The tradeoff is that it’s not suitable for dogs under 51 lbs.

Strength
  • Formulated for large dogs
  • 6-month convenience
  • Trusted brand
  • Covers major parasites
Weakness
  • Not for small dogs
  • Higher cost per dose

5. TRI-HEART PLUS Chewable Tablets for Dogs 26-50 lbs, 6 Month

Best Mid-Size Dog Coverage
TRI-HEART PLUS Chewable Tablets for Dogs 26-50 lbs, 6 Month
8.7

Tri-heart Plus

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Medium-sized dogs also require reliable heartworm and intestinal worm protection, and using the right dosage is important for safety and effectiveness. This product is tailored for that weight range.

TRI-HEART PLUS for 26-50 lbs dogs provides monthly protection in a beef-flavored tablet, making it a practical choice for owners of mid-size breeds. It’s especially useful for households with dogs that fall between small and large size categories.

  • Targeted for 26-50 lbs: Ensures proper dosing for medium dogs
  • 6 chewable tablets: Six months of coverage per box
  • Beef-flavored tablet: Designed for easy administration

Compared to small or large dog formulas, this option prioritizes accurate dosing for mid-size pets. The main tradeoff is that it’s not suitable for dogs outside the 26-50 lbs range.

Strength
  • Sized for medium dogs
  • 6-month supply
  • Easy monthly dosing
  • Beef-flavored for palatability
Weakness
  • Not for small or large dogs
  • Tablet form may not suit all dogs

6. TRI-HEART PLUS Chewable Tablets for Dogs 51-100 lbs, 6 Month

Best for Large Breeds with Allergies
TRI-HEART PLUS Chewable Tablets for Dogs 51-100 lbs, 6 Month
8.5

Tri-heart Plus

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Large dogs with beef allergies need a heartworm preventive that’s both effective and safe for their sensitivities. This product fills that gap, offering broad protection in a beef-flavored tablet that avoids common allergens.

TRI-HEART PLUS for 51-100 lbs dogs is designed for big breeds and those with dietary restrictions. It’s a good fit for owners who want a single solution for both size and allergy needs.

  • Formulated for large dogs: Proper dosing for 51-100 lbs pets
  • Beef-free chewable tablet: Safe for dogs with beef allergies
  • 6-month supply: Reduces frequency of repurchasing

Compared to standard chews, this option prioritizes allergy safety for large dogs. The tradeoff is a firmer tablet texture that may not appeal to every pet.

Strength
  • Safe for beef-sensitive large dogs
  • 6-month coverage
  • Covers heartworm and intestinal worms
  • Monthly dosing
Weakness
  • Tablet may be less palatable
  • Not for smaller dogs

7. Worm X Plus 7 Way Chewables for Small Dogs

Best Value for Small Dog Owners
Worm X Plus 7 Way Chewables for Small Dogs
8.9

Worm X Plus

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Small dogs are at risk from a variety of intestinal worms, not just heartworm. Owners looking for a broad-spectrum, over-the-counter solution often want something easy to give and cost-effective.

Worm X Plus 7 Way Chewables offer broad parasite coverage, including tapeworms, roundworms, and hookworms, in a chewable format suitable for dogs 6 to 25 lbs. It’s a smart pick for those seeking value and flexibility without a prescription.

  • Broad-spectrum dewormer: Treats seven types of worms, including tapeworms
  • Over-the-counter access: No prescription required for purchase
  • Easy chewable tablets: Can be given with or without food

Compared to prescription-only options, this product prioritizes accessibility and multi-worm coverage. The tradeoff is that it does not protect against heartworm, so it may need to be paired with a separate preventive.

Strength
  • Treats multiple worm types
  • No prescription needed
  • Affordable for regular use
  • Easy to administer
  • Suitable for small dogs and puppies
Weakness
  • Does not prevent heartworm
  • Requires separate heartworm medication

Buying Guide: How to Choose the Best Heartworm and Dewormer Chewables for Small Dogs

Selecting the right chewable for your small dog involves understanding the differences between heartworm preventives and broad-spectrum dewormers. Many owners assume all chewables offer the same protection, but products vary in parasite coverage, dosing, and suitability for allergies. It's important to match your dog's needs with the correct formula and administration method.

Choosing Between Heartworm Preventives and Broad Dewormers

Many owners confuse heartworm prevention with general deworming. Heartworm preventives like HEARTGARD and TRI-HEART PLUS protect against heartworm and some intestinal worms, but do not cover tapeworms. Dewormers like Worm X Plus treat a wider range of intestinal parasites but do not prevent heartworm. Choose based on your dog's risk factors and veterinary advice.

Matching Product to Dog Size and Lifestyle

Using the correct product for your dog's weight is essential for safety and effectiveness. Products are specifically formulated for small, medium, or large dogs. If you have multiple dogs of different sizes, you may need more than one product type. Consider your dog's exposure to parasites based on their environment and habits.

Allergy and Palatability Concerns

Some dogs have allergies to beef or other proteins commonly used in chewable flavoring. Beef-free options like TRI-HEART PLUS are available for sensitive pets. Palatability also matters—some dogs prefer soft chews, while others do fine with tablets. If your dog refuses one type, try another format.

Supply Duration: Single Dose vs. Multi-Month Packs

Single-dose packs are useful for first-time users or when testing for side effects. Multi-month supplies offer convenience and often better value but require a higher upfront investment. Choose based on your comfort with the product and your dog's ongoing needs.

Final Buying Advice

Choosing the right chewable comes down to matching your dog's health profile and your preferences as an owner. Avoid assuming all products offer the same protection, and always consult your vet if unsure.

FAQ For Heartguard Plus Small Dogs 0-22lbs Chewables

1. Do all chewable dewormers prevent heartworm?

No, only prescription heartworm preventives like HEARTGARD and TRI-HEART PLUS protect against heartworm. Over-the-counter dewormers like Worm X Plus do not.

2. How do I choose the right dose for my dog?

Select a product that matches your dog's current weight. Using the wrong size can reduce effectiveness or cause side effects.

3. Are beef-flavored chews safe for dogs with allergies?

Not all dogs tolerate beef. If your dog has a beef allergy, choose a beef-free option like TRI-HEART PLUS.

4. Can I use a dewormer and a heartworm preventive together?

Yes, if your dewormer does not cover heartworm, you should use a separate heartworm preventive as recommended by your veterinarian.

5. How often should I give these chewables?

Most products are given once a month. Always follow the instructions on the package or your veterinarian's advice.

6. Is a prescription required for all products?

Prescription is required for heartworm preventives like HEARTGARD and TRI-HEART PLUS, but not for over-the-counter dewormers like Worm X Plus.

James Vega

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